Protein Details: Transient receptor potential channel mucolipin 3

Protein ID

ICDB_Pro_1316

Protein Name

Transient receptor potential channel mucolipin 3

Gene Name

MCOLN3

Organism

Homo sapiens (Human)

Length

553 amino acids

AlphaFoldDB

AF-Q8TDD5-F1-model_v4.pdb

Function

Sequence

MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK

PDB Structures

6AYE 6AYF 6AYG

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Autosomal Recessive Nonsyndromic Deafness 107 and Spinocerebellar Ataxia;Autosomal Recessive 26

Location

DOI ID

10.1038/ng1285; 10.1038/nature04727; 10.1038/emboj.2008.56; 10.1111/j.1600-0854.2009.00935.x; 10.1111/j.1600-0854.2009.00924.x; 10.1074/jbc.m109.078204; 10.1002/jcp.21956; 10.1074/jbc.m110.169185; 10.1371/journal.pone.0058174; 10.1038/nsmb.3502

RefSeq

NP_001240622.1 [Q8TDD5-2]; NP_060768.8 [Q8TDD5-1]; XP_005271060.1 [Q8TDD5-1]; XP_006710813.1;